Why store Cord Lining
When you opt to save your cord lining, you are also saving the stem cells found in it. Studies have revealed that cord lining is a robust type of tissue and it serves as a rich source of stem cells. This is due to its larger surface area and higher density of cells which are present within it1. Theoretically, there are about 20 million stem cells that can be obtained from each square centimeter of cord lining1. There is also potential to harvest other types of novel cells when it is discovered in the future. By storing the cord lining, you are basically storing an unmanipulated source of stem cell.
StemLife is a company in Malaysia with the exclusive license to the patented technology, CellOptima™ . This patent covers the isolation and expansion of Epithelial Stem Cells (EpSC) and Mesenchymal Stem Cells (MSC) from the cord lining. In contrast, cord blood contains mostly Haematopoetic (or blood-forming) stem cells (HSC). Storing both cord blood and cord lining therefore allows for the recovery of HSC, MSC and EpSC. You are availing your child to a medical advancement with access to a growing number of applications of stem cells and the therapeutic potential that they hold. These cells, which can only be collected at birth, are the youngest and most potent available.
7 Key Features of Cord Lining derived MSC
(compared to Wharton’s Jelly Source 1,2,3)
Higher density of MSC in Cord Lining (i.e. 20 million cells per cm2).
When the need arises, the waiting time needed for cell expansion and number of passages for them to reach the desired cell dosage will be shortened.
Greater proliferative capability.
They are able to grow better during cell expansion
Cord lining cells are younger
Patients receiving such stem cells have a lower risk of graft versus host disease.
More robust and tough cells
During cell expansion, they are able to go through more passages without mutation to reach an even greater amount of cell dosage.
Better multi-potency (especially in forming bone and fat)
More superior in modulating host’s immune cells
They have longest survival rates and lowest stimulation to host’s immune system during transplantation. It reduces the chance of rejection by the host.
Able to migrate faster to the affected area.
This helps to shorten time of engraftment and improves outcome of transplantation.
- Ivor J. Lim and T.T. Phan, Cell Transplantation, Vol. 23, pp. 497-503, 2014
- Mandy Stubbendorff, Tobias Deuse et.al., stem cells and development, Vol. 22, Number 19, 2013
- Marc G. Jeschke et al, The Open Tissue Engineering and Regenerative Medicine Journal, 2011, 4, 21-27.